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Plant sizing: how to choose the design loop exit temperature and temperature difference ?

I have a hot water loop with everything set to 40 °C:

  • The design water outlet temperature of my Boiler.
  • The setpoint manager (Hot water temperature schedule, including design day profiles).
  • The rated Inlet water temperature of my Coils.

The flow rate and capacity of systems are autosized.

My question is about these two fields:

What is the right way to choose these parameters ? I have observed they have a significant impact on simulation results. Depending on theses values, I also have some sizing errors (it seems that I need a high value for Design Loop Exit Temperature).