Did you have a look at jEPlus+EA? It's a tool where you input a jEPlus parametric model and it performs multi-objective optimization through Genetic Algorithm. You just need to define your objectives in the rvx file, then launch the jEPlus project in jEPlus+EA. If your solution space is limited, you also have the option to run all jobs in jEPlus and then perform the multi-objective optimization manually as a post-process. If you give more detail about the problems you are finding I can try being more specific and expand to an answer.

Thanks @jack_l Actually i was just reading your paper "An analysis methodology for large-scale deep energy retrofits of existing building stocks: Case study of the Italian office building". that's pretty much what i want to achive, well at least the first part of the optimun for a minimize life-cycle costs and maximize energy use saving. yeah i already check jEPlus +EA i think it's perfect for this, it's just i'm having some problems at using it. May i aske you a few questions about it? and if i can, should i do it here? Thanks a lot Giacomo. Best regards

Thanks @jack_l I just send you an email, sorry for the delay, i was having some problems with the idf file.