The answer is Yes. Why not try? You can model it in a few minutes.minites.

I just added two HeatExchanger:AirToAir:SensibleAndLatent objects before OutdoorAir:Mixer to an ExampleFile 5ZoneWarmest.idf. No coil is added between the HEXs, but you can do so.

5ZoneWarmest_2HEXs.idf (V23-2-0)

BTW, I haven't seen two Enthalpy Wheels system at least in East Asia. Desiccant Wheel (HeatExchanger:Desiccant:BalancedFlow) or Desiccant Wheel + Sensible/Enthalpy Wheel is often used for efficient dehumidification.