Hello,

I use the R package eplusr for the parametric analysis, optimization and calibration jobs. The main advantage is R programming. It can manage large amount of data for the analysis and the visualization of the results. You can also create your own measures. However you need to know how to program in R. There is an equivalent package for Python called Eppy.

If you want something more user friendly, I think the alternative is the PAT tool from tools of OpenStudio.