I would start by double checking your Infiltration and more importantly the mechanical ventilation / outdoor air.

Ensure that you are using DesignSpecification:OutdoorAir (those are best set at the SpaceType level), and correctly setting parameters paremeters on your AirLoopHVACOutdoorAirSystem and Controller:OutdoorAir objects for each loop (especially if it's a DOAS with 100% outside air, you need to force the Minimum Outdoor Air schedule of the Controller:OutdoorAir to always on.

Controller:Mechanical ventilation. Request Output:Variables to check that your zones are getting the correct amount of outdoor air at all times.